Which TCA is specifically indicated for obsessive-compulsive disorder (OCD)?

Clomipramine is specifically indicated for the treatment of obsessive-compulsive disorder (OCD), making it the correct choice. It is a tricyclic antidepressant (TCA) that has been shown to have a strong efficacy in reducing the symptoms of OCD. Clomipramine works by inhibiting the reuptake of serotonin and norepinephrine, which can help modulate the neurotransmitter activity associated with obsessive thoughts and compulsive behaviors.

This particular action on serotonin is key because studies have demonstrated its effectiveness in decreasing both obsessional thoughts and compulsive actions in individuals with OCD. Therefore, clomipramine has received recognition as a first-line treatment option in numerous clinical guidelines for OCD, distinguishing it from other TCAs that do not have the same level of evidence supporting their use specifically for this condition.

On the other hand, while imipramine, doxepin, and amoxapine are all tricyclic antidepressants, they are not specifically indicated for the treatment of OCD and do not have the same level of empirical support in this context.