Which SSRI has the highest incidence of gastrointestinal side effects?

Sertraline is known to have the highest incidence of gastrointestinal side effects among selective serotonin reuptake inhibitors (SSRIs). This class of medications often leads to side effects such as nausea, diarrhea, and abdominal discomfort because they increase serotonin levels, which can affect the gastrointestinal tract. Sertraline, in particular, tends to cause these side effects more frequently than other SSRIs due to its pharmacological properties and the individual variability in patient responses. The gastrointestinal system is sensitive to changes in serotonin levels, and sertraline's strong affinity for serotonin reuptake is a contributing factor to these adverse effects. Understanding the side effect profile of sertraline can help clinicians anticipate and manage these common issues during treatment.