Which antipsychotic approved for MDD is known to be more sedating?

Quetiapine is recognized for its sedative properties, making it particularly effective for individuals with Major Depressive Disorder (MDD) who may also experience insomnia or anxiety. This sedative effect arises from the drug's action as an antagonist at histamine H1 receptors, which contributes to increased sedation and drowsiness.

In the context of treating MDD, the sedative qualities of Quetiapine can be beneficial for patients struggling with sleep disturbances, a common comorbidity with depression. This is one of the reasons it has been approved as an adjunct treatment for major depressive disorder alongside traditional antidepressants.

In contrast, the other antipsychotics mentioned have different profiles regarding sedation. For example, Aripiprazole and Brexpiprazole tend to be more activating and may not provide the same level of sedation as Quetiapine. Ziprasidone can also be less sedating, making Quetiapine the standout choice when considering sedative effects in the context of MDD.