What side effect is more pronounced with the use of SNRIs compared to SSRIs?

The side effect that is more pronounced with the use of serotonin-norepinephrine reuptake inhibitors (SNRIs) compared to selective serotonin reuptake inhibitors (SSRIs) is increased blood pressure. SNRIs, by their mechanism of action, increase the levels of both serotonin and norepinephrine in the brain. This increase in norepinephrine can lead to elevated blood pressure in some patients.

While SSRIs primarily influence serotonin levels, they typically have less effect on norepinephrine and thus do not have the same propensity for causing increases in blood pressure. Patients on SNRIs should be monitored for blood pressure changes, particularly those who may have pre-existing hypertension or cardiovascular concerns.

The other side effects listed, such as dry mouth and decreased libido, can occur with both SNRIs and SSRIs, though they may appear at varying frequencies or severities. Severe headaches are not uniquely linked to SNRIs in the same pronounced manner as increased blood pressure, making the latter the most notable difference between these two classes of antidepressants.