What is the maximum recommended dose of Vilazodone when taken with CYP3A4 inhibitors?

The maximum recommended dose of Vilazodone when taken with CYP3A4 inhibitors is 20 mg once daily. This dosage recommendation is based on the pharmacokinetics of Vilazodone, particularly its metabolism involving the CYP3A4 enzyme. CYP3A4 inhibitors can significantly increase the plasma concentration of Vilazodone, leading to a higher risk of side effects. Therefore, the dosage is carefully adjusted to ensure safety and efficacy, which is why the guideline specifies this limit when patients are also taking medications that inhibit CYP3A4. Following these dosage guidelines helps prevent adverse reactions while still providing effective treatment for conditions such as depression and anxiety.