What is the commonly recommended starting dose of Lithium for elderly and renally impaired patients?

The commonly recommended starting dose of Lithium for elderly and renally impaired patients is 300 mg/day. This recommendation takes into account the pharmacokinetics of Lithium, particularly how its clearance can be affected by age and renal function. In elderly patients, the metabolism and excretion of many drugs, including Lithium, can be slower due to decreased renal function and changes in body composition, which would necessitate starting at a lower dose to avoid toxicity.

Additionally, many clinical guidelines suggest initiating treatment at lower doses in these populations to allow for close monitoring of renal function, serum Lithium levels, and potential side effects. Starting at 300 mg/day allows for gradual titration based on therapeutic response and tolerance, ensuring that safety is prioritized. As a result, utilizing this starting dosage is especially critical in managing patient care effectively and safely.