Kava-kava is known to potentially cause which adverse effect?

Kava-kava is primarily associated with hepatotoxicity, which refers to liver damage. This adverse effect has been substantiated by various clinical reports and regulatory warnings regarding the use of kava-kava in dietary supplements and herbal products. The liver is responsible for metabolizing many substances, including herbal supplements, and kava has been linked to cases of liver injury, even leading to severe conditions such as hepatitis and liver failure in some instances.

Research indicates that kava can affect liver enzyme functions and alter the liver's ability to process toxins and medications, which can exacerbate potential risk factors for liver injury. Consequently, healthcare providers caution against the use of kava, especially in individuals with pre-existing liver conditions or those who consume other substances that may also impact liver health.

In contrast, nephrotoxicity (kidney damage), gastrotoxicity (gastrointestinal damage), and neurotoxicity (damage to the nervous system) are less commonly associated with kava use, making hepatotoxicity the more prominent concern.